丙肝病毒迄今最详细的图像

时间：2013-11-29 08:14:01

（单词翻译:单击）

Scientists at The Scripps Research Institute (TSRI) have determined¹ the most detailed² picture yet of a crucial part of the hepatitis（肝炎） C virus, which the virus uses to infect liver cells. The new data reveal unexpected structural³ features of this protein and should greatly speed efforts to make an effective hepatitis C vaccine⁴. The findings, which appear in the November 29, 2013 issue of the journal Science, focus on a protein known as E2 envelope glycoprotein（包膜糖蛋白）.

"We're excited by this development," said Ian A. Wilson, the Hansen Professor of Structural Biology at TSRI and a senior author of the new research with TSRI Assistant Professors Mansun Law and Andrew B. Ward⁵. "It has been very hard to get a high resolution structure of E2 and it took years of painstaking⁶ work to finally accomplish that."

Any successful hepatitis C vaccine is likely to target the E2 protein. Scientists already have isolated⁷ rare antibodies from patients that can bind⁸ E2 in ways that neutralize⁹ a broad range of viral strains.

"It took our team six years to crack this very difficult scientific problem, but we didn't give up," said Law. "Now that we can visualize¹⁰ the structural details of these binding¹¹ sites, we can design vaccine molecules¹² that mimic¹³ them."

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1 determined
adj.坚定的；有决心的
参考例句：
I have determined on going to Tibet after graduation.我已决定毕业后去西藏。 He determined to view the rooms behind the office.他决定查看一下办公室后面的房间。

2 detailed
adj.详细的，详尽的，极注意细节的，完全的
参考例句：
He had made a detailed study of the terrain.他对地形作了缜密的研究。 A detailed list of our publications is available on request.我们的出版物有一份详细的目录备索。

3 structural
adj.构造的，组织的，建筑（用）的
参考例句：
The storm caused no structural damage.风暴没有造成建筑结构方面的破坏。 The North American continent is made up of three great structural entities.北美大陆是由三个构造单元组成的。

4 vaccine
n.牛痘苗，疫苗；adj.牛痘的，疫苗的
参考例句：
The polio vaccine has saved millions of lives.脊髓灰质炎疫苗挽救了数以百万计的生命。 She takes a vaccine against influenza every fall.她每年秋季接种流感疫苗。

5 ward
n.守卫，监护，病房，行政区，由监护人或法院保护的人（尤指儿童）；vt.守护，躲开
参考例句：
The hospital has a medical ward and a surgical ward.这家医院有内科病房和外科病房。 During the evening picnic,I'll carry a torch to ward off the bugs.傍晚野餐时，我要点根火把，抵挡蚊虫。

6 painstaking
adj.苦干的；艰苦的，费力的，刻苦的
参考例句：
She is not very clever but she is painstaking.她并不很聪明，但肯下苦功夫。 Through years of our painstaking efforts,we have at last achieved what we have today.大家经过多少年的努力，才取得今天的成绩。

7 isolated
adj.与世隔绝的
参考例句：
His bad behaviour was just an isolated incident. 他的不良行为只是个别事件。 Patients with the disease should be isolated. 这种病的患者应予以隔离。

8 bind
vt.捆，包扎；装订；约束；使凝固；vi.变硬
参考例句：
I will let the waiter bind up the parcel for you.我让服务生帮你把包裹包起来。 He wants a shirt that does not bind him.他要一件不使他觉得过紧的衬衫。

9 neutralize
v.使失效、抵消，使中和
参考例句：
Nothing could neutralize its good effects.没有什么能抵消它所产生的好影响。 Acids neutralize alkalis and vice versa.酸能使碱中和碱，亦能使酸中和。

10 visualize
vt.使看得见，使具体化，想象，设想
参考例句：
I remember meeting the man before but I can't visualize him.我记得以前见过那个人，但他的样子我想不起来了。 She couldn't visualize flying through space.她无法想像在太空中飞行的景象。

11 binding
有约束力的，有效的，应遵守的
参考例句：
The contract was not signed and has no binding force. 合同没有签署因而没有约束力。 Both sides have agreed that the arbitration will be binding. 双方都赞同仲裁具有约束力。

12 molecules
分子( molecule的名词复数 )
参考例句：
The structure of molecules can be seen under an electron microscope. 分子的结构可在电子显微镜下观察到。 Inside the reactor the large molecules are cracked into smaller molecules. 在反应堆里，大分子裂变为小分子。

13 mimic
v.模仿，戏弄；n.模仿他人言行的人
参考例句：
A parrot can mimic a person's voice.鹦鹉能学人的声音。 He used to mimic speech peculiarities of another.他过去总是模仿别人讲话的特点。