细胞内复杂的调控机制

时间：2013-09-23 08:03:13

（单词翻译:单击）

Molecular1 microbiologists at the University of Southern California (USC) have uncovered intricate（复杂的） regulatory mechanisms3 within the cell that could lead to novel therapeutics for the treatment of cancer and other diseases. Their findings, which have long-standing significance in the basic understanding of cell biology, appear in the journal Nature Cell Biology. "Our research reveals a new regulatory mechanism2 that coordinates4 two distinct intracellular processes that are critical to cellular5 homeostasis（自动调节） and disease development," said Chengyu Liang, M.D., Ph.D., a member of the USC Norris Comprehensive Cancer Center and principal investigator6 of the study.
 
The endoplasmic reticulum (ER内质网) and Golgi apparatus7 are cellular organelles in eurkaryotic organisms where proteins are synthesized and packaged for secretion8 through the body. The trafficking of proteins between the ER and Golgi must be tightly modulated9 to maintain the health of the cell and prevent diseases like cancer from taking hold.
 
"Interest in the role of ER-Golgi network during cancer cell death has been gaining momentum," said Shanshan He, Ph.D., research associate at the Keck School of Medicine of USC and one of the study's first authors. "In this study, we identified a novel regulatory factor for the Golgi-ER retrograde（倒退的） transport and a new mechanistic connection between the physiological10 trafficking and the autophagic transportation of cellular material."
 
The researchers discovered that the UV irradiation resistance-associated gene11 protein (UVRAG), which has been implicated12 in the suppression of colon13 and breast cancer, coordinates trafficking of proteins between the ER and Golgi apparatus and also autophagy（自我吞噬）, the natural process of breaking down cellular components14.
 
"Given that the ER-Golgi network is often dismantled15 in malignant16 conditions and that UVRAG is intensively involved in different types of human cancers, this study gives us a new avenue to investigate anti-cancer agents that target UVRAG and/or the ER-Golgi pathway in cancer and other relevant diseases," Liang said.

分享到：


点击收听单词发音收听单词发音  

1 molecular mE9xh     
adj.分子的；克分子的
参考例句：
  • The research will provide direct insight into molecular mechanisms.这项研究将使人能够直接地了解分子的机理。
  • For the pressure to become zero, molecular bombardment must cease.当压强趋近于零时，分子的碰撞就停止了。
2 mechanism zCWxr     
n.机械装置；机构，结构
参考例句：
  • The bones and muscles are parts of the mechanism of the body.骨骼和肌肉是人体的组成部件。
  • The mechanism of the machine is very complicated.这台机器的结构是非常复杂的。
3 mechanisms d0db71d70348ef1c49f05f59097917b8     
n.机械( mechanism的名词复数 )；机械装置；[生物学] 机制；机械作用
参考例句：
  • The research will provide direct insight into molecular mechanisms. 这项研究将使人能够直接地了解分子的机理。 来自《简明英汉词典》
  • He explained how the two mechanisms worked. 他解释这两台机械装置是如何工作的。 来自《简明英汉词典》
4 coordinates 8387d77faaaa65484f5631d9f9d20bfc     
n.相配之衣物；坐标( coordinate的名词复数 )；（颜色协调的）配套服装；[复数]女套服；同等重要的人（或物）v.使协调，使调和( coordinate的第三人称单数 )；协调；协同；成为同等
参考例句：
  • The town coordinates on this map are 695037. 该镇在这幅地图上的坐标是695037。 来自《简明英汉词典》
  • The UN Office for the Coordination of Humanitarian Affairs, headed by the Emergency Relief Coordinator, coordinates all UN emergency relief. 联合国人道主义事务协调厅在紧急救济协调员领导下，负责协调联合国的所有紧急救济工作。 来自《简明英汉词典》
5 cellular aU1yo     
adj.移动的；细胞的，由细胞组成的
参考例句：
  • She has a cellular telephone in her car.她的汽车里有一部无线通讯电话机。
  • Many people use cellular materials as sensitive elements in hygrometers.很多人用蜂窝状的材料作为测量温度的传感元件。
6 investigator zRQzo     
n.研究者，调查者，审查者
参考例句：
  • He was a special investigator for the FBI.他是联邦调查局的特别调查员。
  • The investigator was able to deduce the crime and find the criminal.调查者能够推出犯罪过程并锁定罪犯。
7 apparatus ivTzx     
n.装置，器械；器具，设备
参考例句：
  • The school's audio apparatus includes films and records.学校的视听设备包括放映机和录音机。
  • They had a very refined apparatus.他们有一套非常精良的设备。
8 secretion QDozG     
n.分泌
参考例句：
  • Is there much secretion from your eyes?你眼里的分泌物多吗？
  • In addition,excessive secretion of oil,water scarcity are also major factors.除此之外，油脂分泌过盛、缺水也都是主要因素。
9 modulated b5bfb3c5c3ebc18c62afa9380ab74ba5     
已调整[制]的，被调的
参考例句：
  • He carefully modulated his voice. 他小心地压低了声音。
  • He had a plump face, lemur-like eyes, a quiet, subtle, modulated voice. 他有一张胖胖的脸，狐猴般的眼睛，以及安详、微妙和富于抑扬顿挫的嗓音。
10 physiological aAvyK     
adj.生理学的，生理学上的
参考例句：
  • He bought a physiological book.他买了一本生理学方面的书。
  • Every individual has a physiological requirement for each nutrient.每个人对每种营养成分都有一种生理上的需要。
11 gene WgKxx     
n.遗传因子，基因
参考例句：
  • A single gene may have many effects.单一基因可能具有很多种效应。
  • The targeting of gene therapy has been paid close attention.其中基因治疗的靶向性是值得密切关注的问题之一。
12 implicated 8443a53107b44913ed0a3f12cadfa423     
adj.密切关联的；牵涉其中的
参考例句：
  • These groups are very strongly implicated in the violence. 这些组织与这起暴力事件有着极大的关联。 来自《简明英汉词典》
  • Having the stolen goods in his possession implicated him in the robbery. 因藏有赃物使他涉有偷盗的嫌疑。 来自《现代汉英综合大词典》
13 colon jqfzJ     
n.冒号，结肠，直肠
参考例句：
  • Here,too,the colon must be followed by a dash.这里也是一样，应当在冒号后加破折号。
  • The colon is the locus of a large concentration of bacteria.结肠是大浓度的细菌所在地。
14 components 4725dcf446a342f1473a8228e42dfa48     
（机器、设备等的）构成要素，零件，成分； 成分( component的名词复数 )； [物理化学]组分； [数学]分量； （混合物的）组成部分
参考例句：
  • the components of a machine 机器部件
  • Our chemistry teacher often reduces a compound to its components in lab. 在实验室中化学老师常把化合物分解为各种成分。
15 dismantled 73a4c4fbed1e8a5ab30949425a267145     
拆开( dismantle的过去式和过去分词 )； 拆卸； 废除； 取消
参考例句：
  • The plant was dismantled of all its equipment and furniture. 这家工厂的设备和家具全被拆除了。
  • The Japanese empire was quickly dismantled. 日本帝国很快被打垮了。
16 malignant Z89zY     
adj.恶性的，致命的；恶意的，恶毒的
参考例句：
  • Alexander got a malignant slander.亚历山大受到恶意的诽谤。
  • He started to his feet with a malignant glance at Winston.他爬了起来，不高兴地看了温斯顿一眼。

©2005-2010英文阅读网