细胞运动性与环境浓度

What do wound healing, cancer metastasis, and bacteria colonies have in common? They all involve the collective displacement¹ of biological cells. New research sheds some new light on the physical mechanisms² provoking the displacement of a sheet of cell, known as an epithelium（上皮细胞）. It typically covers our organs including the stomach and intestine³, as well as our epidermis（上皮，表皮）. In a paper about to appear in EPJ E, Martine Ben Amar from Pierre and Marie Curie University in Paris explains the importance of understanding the displacement of the epithelium as a means of influencing the biological process involved in healing. And, ultimately, of helping⁴ to minimise scars. In this study, Ben Amar aims at developing a predictive theoretical physics model based on calculations designed to account for experimental observations.

 

Her model focuses on particular types of displacement, which are due to molecules⁵ -- referred to as morphogens（皮形素） -- that the cells can feel. In fact, cells are sensitive to their concentration and are therefore attracted in their direction in a process called chemotaxis（趋药性）. Cells can also absorb these molecules at their surface as a means of modifying their concentration and therefore their displacement. In addition, the model takes into account physical parameters⁶ such as the substrate friction⁷ and the cohesion⁸ of the overall tissue.

 

Ben Amar found that her theory could be applied⁹ to better understand the irregularities found at the boundaries of the sheets, which are a signature of the collective behaviour of these cells, previously¹⁰ observed in recent in vitro biophysics experiments. Such irregularities could influence the quality of the future scar. This is important for the quality of vision in the case of cornea（角膜） scars, and for a possible improvement in the bio-engineering of artificial tissues.

分享到：