健康足孕宝宝会分泌与母亲相异的压力激素

A University of Calgary researcher has identified how a steroid hormone¹ may indicate infant distress² during labour and delivery. The study, published by PLOS ONE this month, suggests that a full-term, healthy baby preferentially（优先地） secretes³（藏匿，分泌） a different stress hormone than its mother does. That stress hormone, corticosterone（肾上腺酮）, has not been previously⁴ studied in human development. "Fetal corticosterone, which is related to cortisol, could serve as a biomarker of fetal stress," says study lead author Katherine Wynne-Edwards, PhD, Jack⁵ Manns Professor of Comparative Endocrinology. Wynne-Edwards worked with clinical obstetrician/gynecologist Heather Edwards on the study.

 

"Since cortisol is found in much higher concentrations than corticosterone, it has received greater attention as an indicator⁶ of stress in both mothers and newborns."

 

In this study, investigators⁷ compared the concentrations of hormones⁸ in the umbilical（脐带的） cord to assess the hormones added to the circulation by the baby. Corticosterone increased during labor⁹ and delivery at a significantly greater rate compared to cortisol, although overall cortisol levels were still higher. As fetal stress increased, so did corticosterone concentrations.

 

Investigators analyzed¹⁰ umbilical cord blood samples from 265 healthy deliveries. Corticosterone concentrations varied¹¹ according to the delivery -- compared to infants delivered by Caesarian section, vaginally delivered infants synthesized greater concentrations of corticosterone. When Caesarian delivery occurred because the baby's head was too large to pass through the birth canal, which was expected to be a stressor on the baby, the highest corticosterone concentrations were seen. Meanwhile, intervention¹² to strengthen maternal¹³ contractions¹⁴ did not increase corticosterone concentrations.

 

"Newborn corticosterone synthesis might be the basis for a signal to the mother that the baby is in distress, and might also indicate that a previously unsuspected developmental transition from preferential corticosterone synthesis to preferential cortisol synthesis occurs in early life," Wynne-Edwards said. "If so, then corticosterone might be an important biomarker of adrenal function in premature¹⁵ infants that is not yet studied or understood."

 

Wynne-Edwards presented her findings at the Endocrine Society Annual Meeting in San Francisco on June 15, 2013. The study was funded by the Natural Sciences and Engineering Research Council of Canada and an Alberta Advanced Education and Technology grant, through the Faculty¹⁶ of Veterinary Medicine at the University of Calgary.

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