他汀类药物似乎不会造成短期失忆

Cholesterol¹-lowering statin drugs most likely do not cause short-term memory loss, according to a Rutgers University and University of Pennsylvania study of nearly one million patients - contrary to prior assertions. Limited previous studies and some statin-drug takers have anecdotally reported memory lapses² after taking popular lipid-lowering drugs (LLDs) called statins, said Brian L. Strom, chancellor³ of Rutgers Biomedical and Health Sciences (RBHS) and lead study author. The result has been that some people have stopped taking their statins, inappropriately, Strom said.

 

About 610,000 people die of heart disease in the United States every year - that's 1 in every 4 deaths, according to the Centers for Disease Control. One in four Americans over age 45 take statins, drugs that inhibit⁴ a liver enzyme⁵ that controls the synthesis of cholesterol and lowers LDL, commonly known as "bad cholesterol." Statins have proven very effective at lowering high cholesterol, one of the major risk factors for heart disease, and preventing heart attacks and deaths. If a statin drug alone is not effectively reducing cholesterol numbers or a patient doesn't tolerate the drug, nonstatins are often prescribed, Strom said.

 

The study, published today in The Journal of the American Medical Association-Internal Medicine, compared new users of statins with people not taking statins. New statin users also were compared to a second control group - patients taking nonstatin LLDs - which had not been done before. 

 

More patients taking statins indeed reported memory loss in the 30-day period after first taking the drugs, compared to non-users, the study found. The same, however, was found with the nonstatin LLDs. "Either it means that anything that lowers cholesterol has the same effect on short-term memory, which is not scientifically credible⁶ because you're dealing⁷ with drugs with completely different structures," Strom said. Or, he said, "detection bias⁸" is more likely the reason, meaning patients taking a new drug visit their doctors more frequently and are highly attuned⁹ to their health. 

 

"When patients are put on statins or any new drug, they're seen more often by their doctor, or they themselves are paying attention to whether anything is wrong," Strom said. "So if they have a memory problem, they're going to notice it.

 

Even if it has nothing to do with the drug, they're going to blame it on the drug."

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