线粒体与疾病防御体系

Scientists from the Montreal Neurological Institute and Hospital in Canada have discovered that two genes¹ linked to hereditary²（遗传的） Parkinson's disease are involved in the early-stage quality control of mitochondria（线粒体）. The protective mechanism³, which is reported in The EMBO Journal, removes damaged proteins that arise from oxidative stress from mitochondria. "PINK1 and parkin, are implicated⁴ in selectively targeting dysfunctional components⁵ of mitochondria to the lysosome under conditions of excessive oxidative damage within the organelle（细胞器）," said Edward Fon, Professor at the McGill Parkinson Program at the Montreal Neurological Institute and Hospital. "Our study reveals a quality control mechanism where vesicles bud off from mitochondria and proceed to the lysosome for degradation⁶. This method is distinct from the degradation pathway for damaged whole mitochondria which has been known for some time. It is also an early response, proceeding⁷ on a timescale of hours instead of days."

 

The deterioration⁸ of mechanisms⁹ designed to maintain the integrity and function of mitochondria throughout the lifetime of a cell has been suggested to underlie¹⁰ the progression of several neurodegenerative diseases, including Parkinson's disease. When mitochondria, the "power plants" of the cell that provide energy, malfunction¹¹ they can contribute to Parkinson's disease. If they are to survive and function mitochondria need to degrade oxidized and damaged proteins.

 

In the study, immunofluorescence and confocal microscopy were used to observe how the vesicles "pinch off" from mitochondria with their damaged cargo¹². "Our conclusion is that the loss of this PINK1 and parkin-dependent trafficking system impairs¹³ the ability of mitochondria to selectively degrade oxidized and damaged proteins and leads, over time, to the mitochondrial dysfunction noted¹⁴ in hereditary Parkinson's disease," said Heidi McBride, Professor in the Neuromuscular Group in the Department of Neurology and Neurosurgery at the Montreal Neurological Institute and Hospital.

 

Both salvage¹⁵ pathways are operational in the cell. If the vesicular pathway, the first line of defense¹⁶, is overwhelmed and the damage is irreversible then the entire organelle is targeted for degradation.

分享到：