有些动物为何能更长寿

Scientists at the University of Liverpool have developed a new method to detect proteins associated with longevity¹, which helps further our understanding into why some animals live longer than others. The team looked at the genome of more than 30 mammalian（哺乳类） species to identify proteins that evolve in connection with the longevity of a species. They found that a protein, important in responding to DNA² damage, evolves and mutates in a non-random way in species that are longer-lived, suggesting that it is changing for a specific purpose. They found a similar pattern in proteins associated with metabolism³, cholesterol⁴（胆固醇） and pathways involved in the recycling of proteins.

Findings show that if certain proteins are being selected by evolution to change in long-lived mammals like humans and elephants, then it is possible that these species have optimized⁵ pathways that repair molecular⁶ damage, compared to shorter-lived animals, such as mice.

The study, led by Dr Joao Pedro Magalhaes and postgraduate⁷ student, Yang Li, is the first to show evolutionary⁸ patterns in biological repair systems in long-lived animals and could, in the future, be used to help develop anti-aging interventions⁹ by identifying proteins in long-lived species that better respond to, for example, DNA damage. Proteins associated with the degradation¹⁰ of damaged proteins, a process that has been connected to aging, were also linked with the evolution of longevity in mammals.

Dr Magalhaes, from the University's Institute of Integrative Biology, said: "The genetic¹¹ basis for longevity differences between species remains¹² a major puzzle of biology. A mouse lives less than five years and yet humans can live to over 100 for example. If we can identify the proteins that allow some species to live longer than others we could use this knowledge to improve human health and slow the aging process.

"We developed a method to detect proteins whose molecular evolution correlates with longevity of a species. The proteins we detected changed in a particular pattern, suggesting that evolution of these proteins was not by accident, but rather by design to cope with the biological processes impacted by aging, such as DNA damage. The results suggest that long-lived animals were able to optimise bodily repair which will help them fend¹³ off the aging process."

The research is published in the American Aging Association's journal, Age.