纳米微粒 对付癌细胞的“聪明”杀手

Another weapon in the arsenal¹（兵工厂，军械库） against cancer: Nanoparticles that identify, target and kill specific cancer cells while leaving healthy cells alone. Led by Carl Batt, the Liberty Hyde Bailey Professor of Food Science, the researchers synthesized（综合，合成） nanoparticles – shaped something like a dumbbell（哑铃） – made of gold sandwiched between two pieces of iron oxide²（氧化铁） . They then attached antibodies, which target a molecule³ found only in colorectal（结肠直肠的） cancer cells, to the particles. Once bound, the nanoparticles are engulfed⁴（吞没，吞食） by the cancer cells.

To kill the cells, the researchers use a near-infrared laser, which is a wavelength⁵ that doesn't harm normal tissue at the levels used, but the radiation is absorbed by the gold in the nanoparticles. This causes the cancer cells to heat up and die.

"This is a so-called 'smart' therapy," Batt said. "To be a smart therapy, it should be targeted, and it should have some ability to be activated⁶ only when it's there and then kills just the cancer cells."

The goal, said lead author and biomedical graduate student Dickson Kirui, is to improve the technology and make it suitable for testing in a human clinical trial. The researchers are now working on a similar experiment targeting prostate cancer（前列腺癌） cells.

"If, down the line, you could clinically just target the cancer cells, you could then spare the health surrounding cells from being harmed – that is the critical thing," Kirui said.

Gold has potential as a material key to fighting cancer in future smart therapies. It is biocompatible（生物可相容的，不会引起排斥的） , inert⁷（惰性的，迟缓的） and relatively⁸ easy to tweak chemically. By changing the size and shape of the gold particle, Kirui and colleagues can tune⁹ them to respond to different wavelengths¹⁰ of energy.

Once taken up by the researchers' gold particles, the cancer cells are destroyed by heat – just a few degrees above normal body temperature – while the surrounding tissue is left unharmed. Such a low-power laser does not have any effect on surrounding cells because that particular wavelength does not heat up cells if they are not loaded up with nanoparticles, the researchers explained.

Using iron oxide – which is basically rust¹¹（生锈） – as the other parts of the particles might one day allow scientists to also track the progress of cancer treatments using magnetic resonance¹² imaging（磁共振成像） , Kirui said, by taking advantage of the particles' magnetic properties.