Slow blood flow 'hampers statins' 血流缓慢导致“阻碍他汀类”

时间：2009-07-13 06:08:55

（单词翻译:单击）

Slow blood flow in areas of the body's arteries1 may reduce the protective effect of statins, research suggests.

研究显示，身体某些部位的动脉血流缓慢可能导致他汀类的保护作用。

Millions now take statins to protect their heart
Millions now take statins to protect their heart

The study suggests sluggish2（懒惰的，迟钝的） blood flow tends to hinder（阻碍，打扰） statins' ability to trigger production of beneficial antioxidant（抗氧化剂） molecules3.

The body's own protective mechanisms4 also tend to fail in the same areas - leaving them vulnerable to（易受……攻击） damage.

The Imperial College London study is featured in the Journal of Biological Chemistry.

It raises hopes of new ways to improve general artery5（动脉，主流） health.

Statins are estimated to save nearly 10,000 lives a year in England alone by cutting the risk of cardiovascular disease（心血管病）.

Their primary action is to lower levels of harmful LDL cholesterol6（胆固醇） which can clog7（阻塞） up the arteries.

However, they are also thought to stimulate8 production of beneficial antioxidants in the cells of the arteries by boosting levels of a key enzyme9（酶）, called heme oxygenase (HO-1).

Antioxidant potency10

The Imperial team investigated the antioxidant potency（权势） of statins in different parts of the circulation by measuring the amount of HO-1 in the endothelial cells（内皮细胞） that line the arteries.

They found the increase in HO-1 induced（感应的） by the statin was significantly higher in cells exposed to fast and regular blood flow than in cells where blood flow was sluggish or disrupted.

Previous research has shown endothelial cells produce protective biological signals in parts of the artery where blood flow is fast to counter the build up of fatty cholesterol deposits.

But the cells do not react in the same way in areas where blood flow is sluggish.

The latest study reveals that statins fail to work well in exactly the same areas where the body's natural defences are weak.

Researcher Dr Justin Mason said: "Arteries don't clog up in a uniform way.

"Bends and branches of blood vessels11 - where blood flow is disrupted and can be sluggish - are much more prone12 to fatty plaques13（饰板，名牌） building-up and blocking the artery.

"What we have shown is that those regions of the arteries most likely to become diseased are the same regions that may not be benefiting maximally from statin treatment - a double whammy（祸不单行）."

The researchers hope to find other ways to get the most out of statins, or to find other ways to switch on protective mechanisms in vulnerable areas of arteries.

Professor Peter Weissberg, medical director of the British Heart Foundation, which funded the study, said: "This research demonstrates how the physical forces inside blood vessels may influence the local action of drugs such as statins.

"The findings open avenues of investigation14 that could lead to greater health benefits of statins' being realised."


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1 arteries 821b60db0d5e4edc87fdf5fc263ba3f5     
n.动脉( artery的名词复数 )；干线，要道
参考例句：
  • Even grafting new blood vessels in place of the diseased coronary arteries has been tried. 甚至移植新血管代替不健康的冠状动脉的方法都已经试过。 来自《简明英汉词典》
  • This is the place where the three main arteries of West London traffic met. 这就是伦敦西部三条主要交通干线的交汇处。 来自《简明英汉词典》
2 sluggish VEgzS     
adj.懒惰的，迟钝的，无精打采的
参考例句：
  • This humid heat makes you feel rather sluggish.这种湿热的天气使人感到懒洋洋的。
  • Circulation is much more sluggish in the feet than in the hands.脚部的循环比手部的循环缓慢得多。
3 molecules 187c25e49d45ad10b2f266c1fa7a8d49     
分子( molecule的名词复数 )
参考例句：
  • The structure of molecules can be seen under an electron microscope. 分子的结构可在电子显微镜下观察到。
  • Inside the reactor the large molecules are cracked into smaller molecules. 在反应堆里，大分子裂变为小分子。
4 mechanisms d0db71d70348ef1c49f05f59097917b8     
n.机械( mechanism的名词复数 )；机械装置；[生物学] 机制；机械作用
参考例句：
  • The research will provide direct insight into molecular mechanisms. 这项研究将使人能够直接地了解分子的机理。 来自《简明英汉词典》
  • He explained how the two mechanisms worked. 他解释这两台机械装置是如何工作的。 来自《简明英汉词典》
5 artery 5ekyE     
n.干线，要道；动脉
参考例句：
  • We couldn't feel the changes in the blood pressure within the artery.我们无法感觉到动脉血管内血压的变化。
  • The aorta is the largest artery in the body.主动脉是人体中的最大动脉。
6 cholesterol qrzzV     
n.（U）胆固醇
参考例句：
  • There is cholesterol in the cell of body.人体细胞里有胆固醇。
  • They are determining the serum-protein and cholesterol levels.他们正在测定血清蛋白和胆固醇的浓度。
7 clog 6qzz8     
vt.塞满，阻塞；n.[常pl.]木屐
参考例句：
  • In cotton and wool processing,short length fibers may clog sewers.在棉毛生产中，短纤维可能堵塞下水管道。
  • These streets often clog during the rush hour.这几条大街在交通高峰时间常常发生交通堵塞。
8 stimulate wuSwL     
vt.刺激，使兴奋；激励，使…振奋
参考例句：
  • Your encouragement will stimulate me to further efforts.你的鼓励会激发我进一步努力。
  • Success will stimulate the people for fresh efforts.成功能鼓舞人们去作新的努力。
9 enzyme cPozF     
n.酵素，酶
参考例句：
  • Above a certain temperature,the enzyme molecule will become unfolded.超过一定温度，酶分子将会展开。
  • An enzyme that dissolves the fibrin of blood clots.能溶解血凝块中的纤维的酶。
10 potency 9Smz8     
n. 效力，潜能
参考例句：
  • Alcohol increases the drug's potency.酒精能增加这种毒品的效力。
  • Sunscreen can lose its potency if left over winter in the bathroom cabinet.如果把防晒霜在盥洗室的壁橱里放一个冬天，就有可能失效。
11 vessels fc9307c2593b522954eadb3ee6c57480     
n.血管( vessel的名词复数 )；船；容器；（具有特殊品质或接受特殊品质的）人
参考例句：
  • The river is navigable by vessels of up to 90 tons. 90 吨以下的船只可以从这条河通过。 来自《简明英汉词典》
  • All modern vessels of any size are fitted with radar installations. 所有现代化船只都有雷达装置。 来自《现代汉英综合大词典》
12 prone 50bzu     
adj.(to)易于…的，很可能…的；俯卧的
参考例句：
  • Some people are prone to jump to hasty conclusions.有些人往往作出轻率的结论。
  • He is prone to lose his temper when people disagree with him.人家一不同意他的意见,他就发脾气。
13 plaques cc23efd076b2c24f7ab7a88b7c458b4f     
（纪念性的）匾牌( plaque的名词复数 )； 纪念匾； 牙斑； 空斑
参考例句：
  • Primary plaques were detectable in 16 to 20 hours. 在16到20小时内可查出原发溶斑。
  • The gondoliers wore green and white livery and silver plaques on their chests. 船夫们穿着白绿两色的制服，胸前别着银质徽章。
14 investigation MRKzq     
n.调查，调查研究
参考例句：
  • In an investigation,a new fact became known, which told against him.在调查中新发现了一件对他不利的事实。
  • He drew the conclusion by building on his own investigation.他根据自己的调查研究作出结论。

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